This handbook is specifically devoted to presenting methods for building culturally appropriate strategies and policies in relation to HIV/AIDS Prevention and Care. The joint UNESCO/UNAIDS Project " A Cultural Approach to HIV/AIDS Prevention and Care" was launched in mid-1998, in relation to the new approach inaugurated by UNAIDS to HIV/AIDS prevention and care. The UNAIDS strategy emphasizes the necessity of giving priority to the multi-dimensional configuration of the issue and to the diversity of its environment, in order to build comprehensive and adaptable strategies and policies.